You may use mod_fastcgi to integrate with your php-fpm. Unfortunately, it seems not support Apache 2.4 at the moment. Alternatively, you can use ByteInternet/libapache-mod-fastcgi Or use mod_proxy_fcgi instead. Configuration for DocumentRoot For virtual hosts, please add ProxyPassMatch for each virtualhost Reference: http://wiki.apache.org/httpd/PHP-FPM